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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50345675
Substrate
n/a
Meas. Tech.
ChEMBL_750511 (CHEMBL1786272)
IC50
1498±n/a nM
Citation
 Lainé, DI; Wan, Z; Yan, H; Zhu, C; Xie, H; Fu, W; Busch-Petersen, J; Neipp, C; Davis, R; Widdowson, KL; Blaney, FE; Foley, J; Bacon, AM; Webb, EF; Luttmann, MA; Burman, M; Sarau, HM; Salmon, M; Palovich, MR; Belmonte, K Design, synthesis, and structure-activity relationship of tropane muscarinic acetylcholine receptor antagonists. J Med Chem 52:5241-52 (2010) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:
Enzyme
Mol. Mass.:
66151.03
Organism:
Homo sapiens (Human)
Description:
P20309
Residue:
590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
  
Inhibitor
Name:
BDBM50345675
Synonyms:
(endo-8-methyl-8-azabicyclo[3.2.1]octan-3-yl)diphenylmethanol | CHEMBL1782087
Type:
Small organic molecule
Emp. Form.:
C21H25NO
Mol. Mass.:
307.4293
SMILES:
CN1[C@@H]2CC[C@@H]1CC(C2)C(O)(c1ccccc1)c1ccccc1 |r,TLB:0:1:7.8.6:3.4,THB:9:7:1:3.4|
Structure:
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