Reaction Details Report a problem with these data
Target
Beta-3 adrenergic receptor
Ligand
BDBM50379086
Substrate
n/a
Meas. Tech.
ChEMBL_809680 (CHEMBL2015899)
EC50
2.4±n/a nM
Citation
 Jesudason, CD; Baker, JE; Bryant, RD; Fisher, JW; Gaich, GA; He, MM; Kahl, SD; Kriauciunas, AV; Heiman, ML; Peters, MA; Rito, CJ; Satterwhite, JH; Tinsley, FC; Trankle, WG; Shuker, AJ Combination of a Beta adrenoceptor modulator and a norepinephrine-serotonin uptake inhibitor for the treatment of obesity. ACS Med Chem Lett 2:583-586 (2011) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50379086
Synonyms:
CHEMBL2012521 | CHEMBL2012522 | LY-377604
Type:
Small organic molecule
Emp. Form.:
C31H32N4O4
Mol. Mass.:
524.6102
SMILES:
CC(C)(Cc1ccc(Oc2ccc(cn2)C(N)=O)cc1)NC[C@H](O)COc1cccc2[nH]c3ccccc3c12 |r|
Structure:
Search PDB for entries with ligand similarity: