Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50379308
Substrate
n/a
Meas. Tech.
ChEMBL_811976 (CHEMBL2013346)
Ki
4.4±n/a nM
Citation
 Mihalic, JT; Kim, YJ; Lizarzaburu, M; Chen, X; Deignan, J; Wanska, M; Yu, M; Fu, J; Chen, X; Zhang, A; Connors, R; Liang, L; Lindstrom, M; Ma, J; Tang, L; Dai, K; Li, L Discovery of a new class of ghrelin receptor antagonists. Bioorg Med Chem Lett 22:2046-51 (2012) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50379308
Synonyms:
CHEMBL2011816
Type:
Small organic molecule
Emp. Form.:
C32H36N4O4
Mol. Mass.:
540.6526
SMILES:
CC(C)[C@@H](N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O)C(=O)NC1CCN(Cc2ccccc2)CC1 |r|
Structure:
Search PDB for entries with ligand similarity: