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Target
Carbonic anhydrase 2
Ligand
BDBM50380149
Substrate
n/a
Meas. Tech.
ChEMBL_811724 (CHEMBL2014299)
Kd
26±n/a nM
Citation
 Capkauskaite, E; Zubriene, A; Baranauskiene, L; Tamulaitiene, G; Manakova, E; Kairys, V; Gražulis, S; Tumkevicius, S; Matulis, D Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases. Eur J Med Chem 51:259-70 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50380149
Synonyms:
CHEMBL2011154
Type:
Small organic molecule
Emp. Form.:
C16H19N3O3S2
Mol. Mass.:
365.47
SMILES:
CCCCc1cnc(SCC(=O)c2ccc(cc2)S(N)(=O)=O)nc1
Structure:
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