Target
D(3) dopamine receptor
Ligand
BDBM50382293
Substrate
n/a
Meas. Tech.
ChEMBL_816863 (CHEMBL2026134)
IC50
1.9±n/a nM
Citation
 Agai-Csongor, EDomány, GNógrádi, KGalambos, JVágó, IKeseru, GMGreiner, ILaszlovszky, IGere, ASchmidt, EKiss, BVastag, MTihanyi, KSághy, KLaszy, JGyertyán, IZájer-Balázs, MGémesi, LKapás, MSzombathelyi, Z Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg Med Chem Lett 22:3437-40 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50382293
Synonyms:
CHEMBL2024506
Type:
Small organic molecule
Emp. Form.:
C21H30F3N3O
Mol. Mass.:
397.4776
SMILES:
CC(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(c2)C(F)(F)F)CC1 |r,wU:4.3,wD:7.7,(32.2,-3.32,;33.53,-2.55,;33.53,-1.01,;34.87,-3.32,;36.2,-2.54,;36.2,-1,;37.53,-.23,;38.86,-1,;40.19,-.24,;41.52,-1.01,;42.86,-.25,;44.18,-1.02,;45.52,-.26,;45.53,1.28,;44.2,2.05,;42.85,1.29,;46.87,2.04,;48.2,1.25,;49.53,2.01,;49.54,3.56,;48.21,4.33,;46.87,3.57,;48.21,5.87,;49.55,6.64,;46.88,6.65,;48.2,7.42,;38.86,-2.54,;37.53,-3.31,)|
Structure:
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