Target
D(3) dopamine receptor
Ligand
BDBM50382299
Substrate
n/a
Meas. Tech.
ChEMBL_816863 (CHEMBL2026134)
IC50
0.41±n/a nM
Citation
 Agai-Csongor, EDomány, GNógrádi, KGalambos, JVágó, IKeseru, GMGreiner, ILaszlovszky, IGere, ASchmidt, EKiss, BVastag, MTihanyi, KSághy, KLaszy, JGyertyán, IZájer-Balázs, MGémesi, LKapás, MSzombathelyi, Z Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg Med Chem Lett 22:3437-40 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50382299
Synonyms:
CHEMBL2024513
Type:
Small organic molecule
Emp. Form.:
C20H26Cl2F3N3O
Mol. Mass.:
452.341
SMILES:
FC(F)(F)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1 |r,wU:7.6,wD:10.10,(-3.18,-12.8,;-3.18,-11.26,;-4.51,-10.49,;-4.52,-12.02,;-1.84,-10.49,;-1.84,-8.95,;-.51,-11.26,;.82,-10.49,;.82,-8.95,;2.15,-8.17,;3.48,-8.95,;4.82,-8.19,;6.15,-8.96,;7.49,-8.19,;8.81,-8.97,;10.14,-8.21,;10.16,-6.67,;8.82,-5.9,;7.48,-6.66,;11.53,-5.97,;12.82,-6.81,;14.2,-6.1,;14.27,-4.57,;12.98,-3.74,;13.06,-2.2,;11.61,-4.44,;10.31,-3.6,;3.48,-10.49,;2.15,-11.25,)|
Structure:
Search PDB for entries with ligand similarity: