Target
D(3) dopamine receptor
Ligand
BDBM50382303
Substrate
n/a
Meas. Tech.
ChEMBL_816863 (CHEMBL2026134)
IC50
0.62±n/a nM
Citation
 Agai-Csongor, EDomány, GNógrádi, KGalambos, JVágó, IKeseru, GMGreiner, ILaszlovszky, IGere, ASchmidt, EKiss, BVastag, MTihanyi, KSághy, KLaszy, JGyertyán, IZájer-Balázs, MGémesi, LKapás, MSzombathelyi, Z Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors. Bioorg Med Chem Lett 22:3437-40 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50382303
Synonyms:
CHEMBL2024519
Type:
Small organic molecule
Emp. Form.:
C23H36Cl2N4O
Mol. Mass.:
455.464
SMILES:
CCN(CC)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1 |r,wU:8.7,wD:11.11,(-.58,-8.63,;.75,-7.86,;.75,-6.32,;-.58,-5.55,;-1.92,-6.32,;2.09,-5.55,;2.09,-4.01,;3.42,-6.33,;4.75,-5.55,;4.75,-4.01,;6.08,-3.24,;7.41,-4.01,;8.75,-3.25,;10.08,-4.02,;11.41,-3.26,;12.74,-4.03,;14.07,-3.27,;14.08,-1.73,;12.75,-.96,;11.41,-1.72,;15.42,-.97,;16.73,-1.79,;18.09,-1.06,;18.14,.48,;16.84,1.29,;16.89,2.83,;15.47,.56,;14.17,1.38,;7.41,-5.55,;6.08,-6.32,)|
Structure:
Search PDB for entries with ligand similarity: