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Target
Adenosine receptor A2a
Ligand
BDBM50382493
Substrate
n/a
Meas. Tech.
ChEMBL_816161 (CHEMBL2024727)
Ki
15.49±n/a nM
Citation
 Congreve, M; Andrews, SP; Doré, AS; Hollenstein, K; Hurrell, E; Langmead, CJ; Mason, JS; Ng, IW; Tehan, B; Zhukov, A; Weir, M; Marshall, FH Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design. J Med Chem 55:1898-903 (2012) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50382493
Synonyms:
CHEMBL2024116
Type:
Small organic molecule
Emp. Form.:
C16H14FN5
Mol. Mass.:
295.3143
SMILES:
Cc1cc(cc(C)n1)-c1nnc(N)nc1-c1ccc(F)cc1
Structure:
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