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Target
Adenosine receptor A1
Ligand
BDBM50382491
Substrate
n/a
Meas. Tech.
ChEMBL_816162 (CHEMBL2024728)
Ki
0.162±n/a nM
Citation
 Congreve, M; Andrews, SP; Doré, AS; Hollenstein, K; Hurrell, E; Langmead, CJ; Mason, JS; Ng, IW; Tehan, B; Zhukov, A; Weir, M; Marshall, FH Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design. J Med Chem 55:1898-903 (2012) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50382491
Synonyms:
CHEMBL2024114 | US10988455, Example 1(xlii)
Type:
Small organic molecule
Emp. Form.:
C15H11ClN4O
Mol. Mass.:
298.727
SMILES:
Nc1nnc(-c2ccc(O)c(Cl)c2)c(n1)-c1ccccc1
Structure:
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