Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50385447
Substrate
n/a
Meas. Tech.
ChEMBL_822962 (CHEMBL2038283)
IC50
460±n/a nM
Citation
 McCoull, WAddie, MSBirch, AMBirtles, SBuckett, LKButlin, RJBowker, SSBoyd, SChapman, SDavies, RDDonald, CSGreen, CPJenner, CKemmitt, PDLeach, AGMoody, GCGutierrez, PMNewcombe, NJNowak, TPacker, MJPlowright, ATRevill, JSchofield, PSheldon, CStokes, STurnbull, AVWang, SJWhalley, DPWood, JM Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg Med Chem Lett 22:3873-8 (2012) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50385447
Synonyms:
CHEMBL2036568
Type:
Small organic molecule
Emp. Form.:
C19H17F2N5O3
Mol. Mass.:
401.3668
SMILES:
Fc1ccccc1Nc1nnc(o1)C(=O)Nc1ccc(N2CCOCC2)c(F)c1
Structure:
Search PDB for entries with ligand similarity: