Reaction Details Report a problem with these data
Target
Intercellular adhesion molecule 1
Ligand
BDBM50386331
Substrate
n/a
Meas. Tech.
ChEMBL_826675 (CHEMBL2051019)
IC50
2.98±n/a nM
Citation
 Zhong, M; Gadek, TR; Bui, M; Shen, W; Burnier, J; Barr, KJ; Hanan, EJ; Oslob, JD; Yu, CH; Zhu, J; Arkin, MR; Evanchik, MJ; Flanagan, WM; Hoch, U; Hyde, J; Prabhu, S; Silverman, JA; Wright, J Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. ACS Med Chem Lett 3:203-206 (2012) [PubMed]  Article 
Target
Name:
Intercellular adhesion molecule 1
Synonyms:
CD_antigen=CD54 | ICAM-1 | ICAM1 | ICAM1_HUMAN | Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 | Intercellular adhesion molecule 1 | Intercellular adhesion molecule-1 | Major group rhinovirus receptor
Type:
PROTEIN
Mol. Mass.:
57831.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_826675
Residue:
532
Sequence:
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
  
Inhibitor
Name:
BDBM50386331
Synonyms:
CHEMBL2048028
Type:
Small organic molecule
Emp. Form.:
C29H24Cl2N2O7S
Mol. Mass.:
615.481
SMILES:
CS(=O)(=O)c1cccc(C[C@H](NC(=O)c2c(Cl)cc3CN(CCc3c2Cl)C(=O)c2ccc3ccoc3c2)C(O)=O)c1 |r|
Structure:
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