Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50386947
Substrate
n/a
Meas. Tech.
ChEMBL_827492 (CHEMBL2051349)
Ki
152±n/a nM
Citation
 Kung, DW; Coffey, SB; Jones, RM; Cabral, S; Jiao, W; Fichtner, M; Carpino, PA; Rose, CR; Hank, RF; Lopaze, MG; Swartz, R; Chen, HT; Hendsch, Z; Posner, B; Wielis, CF; Manning, B; Dubins, J; Stock, IA; Varma, S; Campbell, M; DeBartola, D; Kosa-Maines, R; Steyn, SJ; McClure, KF Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor. Bioorg Med Chem Lett 22:4281-7 (2012) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50386947
Synonyms:
CHEMBL2048812
Type:
Small organic molecule
Emp. Form.:
C26H30N4O3
Mol. Mass.:
446.5414
SMILES:
COc1ccc(OCC(=O)N2CCC3(CN(Cc4ccc(cc4)-n4cccn4)C3)CC2)cc1
Structure:
Search PDB for entries with ligand similarity: