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Target
Serine/threonine-protein kinase PAK 3
Ligand
BDBM50389320
Substrate
n/a
Meas. Tech.
ChEMBL_831792 (CHEMBL2065155)
IC50
<10000±n/a nM
Citation
 Maryanoff, BE; O'Neill, JC; McComsey, DF; Yabut, SC; Luci, DK; Gibbs, AC; Connelly, MA Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket. Bioorg Med Chem Lett 22:5326-9 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PAK 3
Synonyms:
OPHN3 | PAK3 | PAK3_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | Serine/threonine-protein kinase PAK 3 | p21-Activated kinase 3 (PAK3)
Type:
Enzyme
Mol. Mass.:
62298.33
Organism:
Homo sapiens (Human)
Description:
O75914
Residue:
559
Sequence:
MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR
  
Inhibitor
Name:
BDBM50389320
Synonyms:
CHEMBL2063926
Type:
Small organic molecule
Emp. Form.:
C26H35N9S
Mol. Mass.:
505.681
SMILES:
CSc1ccccc1Nc1nc(nc2c(NCC3CC3)ncnc12)N1CCN(CC1)C1CCNCC1
Structure:
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