Reaction Details Report a problem with these data
Target
Somatostatin receptor type 1
Ligand
BDBM50389590
Substrate
n/a
Meas. Tech.
ChEMBL_833918 (CHEMBL2072498)
IC50
>10000±n/a nM
Citation
 Pasternak, A; Feng, Z; de Jesus, R; Ye, Z; He, S; Dobbelaar, P; Bradley, SA; Chicchi, GG; Tsao, KL; Trusca, D; Eiermann, GJ; Li, C; Feng, Y; Wu, M; Shao, Q; Zhang, BB; Nargund, R; Mills, SG; Howard, AD; Yang, L; Zhou, YP Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist. ACS Med Chem Lett 3:289-293 (2012) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 1
Synonyms:
SRIF-2 | SS-1-R | SS1-R | SS1R | SSR1_MOUSE | Smstr1 | Somatostatin receptor 1 | Sstr1
Type:
PROTEIN
Mol. Mass.:
42724.87
Organism:
Mus musculus
Description:
ChEMBL_833918
Residue:
391
Sequence:
MFPNGTASSPSSSPSPSPGSCGEGACSRGPGSGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCASRISTL
  
Inhibitor
Name:
BDBM50389590
Synonyms:
CHEMBL2069502
Type:
Small organic molecule
Emp. Form.:
C25H26N4O
Mol. Mass.:
398.5001
SMILES:
C1CC(CCO1)[C@H]1N[C@H](Cc2c1[nH]c1ccccc21)c1nc(c[nH]1)-c1ccccc1 |r|
Structure:
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