Reaction Details Report a problem with these data
Target
Dual specificity testis-specific protein kinase 2
Ligand
BDBM50390789
Substrate
n/a
Meas. Tech.
ChEMBL_835732 (CHEMBL2071843)
IC50
415±n/a nM
Citation
 He, L; Seitz, SP; Trainor, GL; Tortolani, D; Vaccaro, W; Poss, M; Tarby, CM; Tokarski, JS; Penhallow, B; Hung, CY; Attar, R; Lin, TA Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett 22:5995-8 (2012) [PubMed]  Article 
Target
Name:
Dual specificity testis-specific protein kinase 2
Synonyms:
TESK2 | TESK2_HUMAN | Testicular protein kinase 2
Type:
PROTEIN
Mol. Mass.:
63642.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_835732
Residue:
571
Sequence:
MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFTCEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRRTIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPSKSVISLVFDLDAPGPGTMPLADWQEPLAPPIRRWRSLPGSPEFLHQEACPFVGREESLSDGPPPRLSSLKYRVKEIPPFRASALPAAQAHEAMDCSILQEENGFGSRPQGTSPCPAGASEEMEVEERPAGSTPATFSTSGIGLQTQGKQDG
  
Inhibitor
Name:
BDBM50390789
Synonyms:
CHEMBL2070613
Type:
Small organic molecule
Emp. Form.:
C26H29N7O2S
Mol. Mass.:
503.619
SMILES:
CCC(CC)Oc1cc(C)c(c(C)c1)-c1cc(nc(n1)-c1cnccn1)-c1cnc(NC(=O)NC)s1
Structure:
Search PDB for entries with ligand similarity: