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Target
Dual specificity testis-specific protein kinase 2
Ligand
BDBM50390791
Substrate
n/a
Meas. Tech.
ChEMBL_835732 (CHEMBL2071843)
IC50
252±n/a nM
Citation
 He, L; Seitz, SP; Trainor, GL; Tortolani, D; Vaccaro, W; Poss, M; Tarby, CM; Tokarski, JS; Penhallow, B; Hung, CY; Attar, R; Lin, TA Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett 22:5995-8 (2012) [PubMed]  Article 
Target
Name:
Dual specificity testis-specific protein kinase 2
Synonyms:
TESK2 | TESK2_HUMAN | Testicular protein kinase 2
Type:
PROTEIN
Mol. Mass.:
63642.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_835732
Residue:
571
Sequence:
MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFTCEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRRTIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPSKSVISLVFDLDAPGPGTMPLADWQEPLAPPIRRWRSLPGSPEFLHQEACPFVGREESLSDGPPPRLSSLKYRVKEIPPFRASALPAAQAHEAMDCSILQEENGFGSRPQGTSPCPAGASEEMEVEERPAGSTPATFSTSGIGLQTQGKQDG
  
Inhibitor
Name:
BDBM50390791
Synonyms:
CHEMBL2070615
Type:
Small organic molecule
Emp. Form.:
C23H23N7O2S
Mol. Mass.:
461.539
SMILES:
CCNC(=O)Nc1ncc(s1)-c1cc(nc(n1)-c1cnccn1)-c1c(C)cc(OC)cc1C
Structure:
Search PDB for entries with ligand similarity: