Target
Dual specificity testis-specific protein kinase 1
Ligand
BDBM50390790
Substrate
n/a
Meas. Tech.
ChEMBL_835731 (CHEMBL2071842)
IC50
1133±n/a nM
Citation
 He, LSeitz, SPTrainor, GLTortolani, DVaccaro, WPoss, MTarby, CMTokarski, JSPenhallow, BHung, CYAttar, RLin, TA Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett 22:5995-8 (2012) [PubMed]  Article 
Target
Name:
Dual specificity testis-specific protein kinase 1
Synonyms:
TESK1 | TESK1_HUMAN
Type:
PROTEIN
Mol. Mass.:
67696.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_587103
Residue:
626
Sequence:
MAGERPPLRGPGPGPGEVPGEGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLTRTALTHNQGSVARGGPSATLPRPDPRLSRSRSDLFLPPSPESPPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPLVPPSPFPSTQLPLVTTPETLVQPGTPARRCRSLPSSPELPRRMETALPGPGPPAVGPSAEEKMECEGSSPEPEPPGPAPQLPLAVATDNFISTCSSASQPWSPRSGPVLNNNPPAVVVNSPQGWAGEPWNRAQHSLPRAAALERTEPSPPPSAPREPDEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCEAGSLLCHRGHHAKPPTPSLQLPGARS
  
Inhibitor
Name:
BDBM50390790
Synonyms:
CHEMBL2070614
Type:
Small organic molecule
Emp. Form.:
C22H21N7O2S
Mol. Mass.:
447.513
SMILES:
CNC(=O)Nc1ncc(s1)-c1cc(nc(n1)-c1cnccn1)-c1c(C)cc(OC)cc1C
Structure:
Search PDB for entries with ligand similarity: