Ki Summary

Reaction Details

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Target

Polyunsaturated fatty acid lipoxygenase ALOX15

Ligand

BDBM50143435

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_840271

IC50

16700±n/a nM

Citation

Iranshahi, M; Jabbari, A; Orafaie, A; Mehri, R; Zeraatkar, S; Ahmadi, T; Alimardani, M; Sadeghian, H Synthesis and SAR studies of mono O-prenylated coumarins as potent 15-lipoxygenase inhibitors. Eur J Med Chem57:134-42 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Polyunsaturated fatty acid lipoxygenase ALOX15

Name:

Polyunsaturated fatty acid lipoxygenase ALOX15

Synonyms:

15-Lipoxygenase-1 (15-LOX-1) | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1)

Type:

Protein

Mol. Mass.:

74804.05

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

662

Sequence:

MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI

BDBM50143435

Name

BDBM50143435

Synonyms:

7-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienyloxy)-chromen-2-one | CHEMBL156127

Type

Small organic molecule

Emp. Form.

C24H30O3

Mol. Mass.

366.4932

SMILES

[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#8]-c1ccc2ccc(=O)oc2c1

Structure

n/a