Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetIndoleamine 2,3-dioxygenase
LigandBDBM50391362
Substrate/Competitorn/a
Meas. Tech.ChEMBL_847925
pH6.5±n/a
IC50 80000±n/a nM
Commentsextracted
Citation Röhrig, UFMajjigapu, SRGrosdidier, ABron, SStroobant, VPilotte, LColau, DVogel, PVan den Eynde, BJZoete, VMichielin, O Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition. J Med Chem55:5270-90 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Indoleamine 2,3-dioxygenase
Name:Indoleamine 2,3-dioxygenase
Synonyms:IDO | IDO-1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase
Type:Enzyme
Mol. Mass.:45330.80
Organism:Homo sapiens (Human)
Description:P14902
Residue:403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50391362
NameBDBM50391362
Synonyms:CHEMBL2148000
TypeSmall organic molecule
Emp. Form.C8H6FN3
Mol. Mass.163.1517
SMILESFc1ccccc1-c1c[nH]nn1
Structure
n/a