Target
Cytochrome P450 26A1
Ligand
BDBM50391726
Substrate
n/a
Meas. Tech.
ChEMBL_848138 (CHEMBL2148657)
IC50
5.7±n/a nM
Citation
 Gomaa, MSLim, ASLau, SCWatts, AMIllingworth, NABridgens, CEVeal, GJRedfern, CPBrancale, AArmstrong, JLSimons, C Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates. Bioorg Med Chem 20:6080-8 (2012) [PubMed]  Article 
Target
Name:
Cytochrome P450 26A1
Synonyms:
CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase
Type:
Enzyme
Mol. Mass.:
56216.16
Organism:
Homo sapiens (Human)
Description:
O43174
Residue:
497
Sequence:
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI
  
Inhibitor
Name:
BDBM50391726
Synonyms:
CHEMBL2146987
Type:
Small organic molecule
Emp. Form.:
C20H21BrN4O2
Mol. Mass.:
429.31
SMILES:
COC(=O)C(C)(C)C(c1ccc(Nc2ccc(Br)nc2)cc1)n1ccnc1
Structure:
Search PDB for entries with ligand similarity: