Reaction Details Report a problem with these data
Target
KiSS-1 receptor
Ligand
BDBM50392411
Substrate
n/a
Meas. Tech.
ChEMBL_851682 (CHEMBL2155899)
IC50
0.28±n/a nM
Citation
 Asami, T; Nishizawa, N; Ishibashi, Y; Nishibori, K; Nakayama, M; Horikoshi, Y; Matsumoto, S; Yamaguchi, M; Matsumoto, H; Tarui, N; Ohtaki, T; Kitada, C Serum stability of selected decapeptide agonists of KISS1R using pseudopeptides. Bioorg Med Chem Lett 22:6391-6 (2012) [PubMed]  Article 
Target
Name:
KiSS-1 receptor
Synonyms:
Gpr54 | KISSR_RAT | Kiss1r
Type:
PROTEIN
Mol. Mass.:
42915.37
Organism:
Rattus norvegicus
Description:
ChEMBL_1448383
Residue:
396
Sequence:
MAAEATLGPNVSWWAPSNASGCPGCGVNASDGPGSAPRPLDAWLVPLFFAALMLLGLVGNSLVIFVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALLYPLPTWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALTVSLSIWVGSAAVSAPVLALHRLSPGPHTYCSEAFPSRALERAFALYNLLALYLLPLLATCACYGAMLRHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACWGPIQLFLVLQALGPSGAWHPRSYAAYALKIWAHCMSYSNSALNPLLYAFLGSHFRQAFCRVCPCGPQRQRRPHASAHSDRAAPHSVPHSRAAHPVRVRTPEPGNPVRRSPSVQDEHTAPL
  
Inhibitor
Name:
BDBM50392411
Synonyms:
CHEMBL2151652
Type:
Small organic molecule
Emp. Form.:
C60H82N18O14
Mol. Mass.:
1279.4053
SMILES:
CNC(N)=NCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r,w:4.4|
Structure:
Search PDB for entries with ligand similarity: