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Target
Alpha-1B adrenergic receptor
Ligand
BDBM50393116
Substrate
n/a
Meas. Tech.
ChEMBL_852798 (CHEMBL2156105)
Ki
5.55±n/a nM
Citation
 Romeiro, LA; da Silva Ferreira, M; da Silva, LL; Castro, HC; Miranda, AL; Silva, CL; Noël, F; Nascimento, JB; Araújo, CV; Tibiriçá, E; Barreiro, EJ; Fraga, CA Discovery of LASSBio-772, a 1,3-benzodioxole N-phenylpiperazine derivative with potent alpha 1A/D-adrenergic receptor blocking properties. Eur J Med Chem 46:3000-12 (2011) [PubMed]  Article 
Target
Name:
Alpha-1B adrenergic receptor
Synonyms:
ADA1B_RAT | Adra1b | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha adrenergic receptor 1A and 1B | Alpha-1 Adrenergic Receptor | Alpha-1Adrenoceptor | Alpha-1B adrenergic receptor | Alpha-1B adrenoreceptor | adrenergic Alpha1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
56606.71
Organism:
Rattus norvegicus (rat)
Description:
Receptor binding assays were performed using rat cortical membranes.
Residue:
515
Sequence:
MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
  
Inhibitor
Name:
BDBM50393116
Synonyms:
CHEMBL2153423
Type:
Small organic molecule
Emp. Form.:
C20H24N2O3
Mol. Mass.:
340.4162
SMILES:
COc1ccccc1N1CCN(CCc2ccc3OCOc3c2)CC1
Structure:
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