Reaction Details Report a problem with these data
Target
Farnesyl pyrophosphate synthase
Ligand
BDBM50135821
Substrate
n/a
Meas. Tech.
ChEMBL_850731 (CHEMBL2156000)
IC50
30±n/a nM
Citation
 Mucha, A; Kafarski, P; Berlicki, L Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry. J Med Chem 54:5955-80 (2011) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Homo sapiens (Human)
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
  
Inhibitor
Name:
BDBM50135821
Synonyms:
(Bis-phosphono-methyl)-cycloheptyl-ammonium | (Cycloheptylamino-phosphono-methyl)-phosphonic acid | (cycloheptylamino)methylenediphosphonic acid | (cyloheptylamino)methylene-1,1-bisphosphonate | CHEMBL53950 | Incadronic acid
Type:
Small organic molecule
Emp. Form.:
C8H19NO6P2
Mol. Mass.:
287.1871
SMILES:
OP(O)(O)C(=NC1CCCCCC1)P(O)(O)=O |w:5.5|
Structure:
Search PDB for entries with ligand similarity: