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Target
Farnesyl pyrophosphate synthase
Ligand
BDBM50098390
Substrate
n/a
Meas. Tech.
ChEMBL_850739 (CHEMBL2156008)
Ki
11±n/a nM
Citation
 Mucha, A; Kafarski, P; Berlicki, L Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry. J Med Chem 54:5955-80 (2011) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
FPPS
Type:
PROTEIN
Mol. Mass.:
40961.27
Organism:
Leishmania major
Description:
ChEMBL_850739
Residue:
362
Sequence:
MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAEAMAKDTQMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVTAQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKLDAKVAHANTTDYVEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTLEKVDKKATHKVAMVMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGSTDPAAVAVIKQLYTEQNLLARFEEYEKAVVAEVEQLIAALEAQNAAFAASVKVLWSKTYKRQK
  
Inhibitor
Name:
BDBM50098390
Synonyms:
(3-methylpyridin-2-ylamino)methylenediphosphonic acid | 2-[(Bis-phosphono-methyl)-amino]-3-methyl-pyridinium | 2-{[hydrogen phosphonato(phosphonato)methyl]amino}-3-methylpyridin-1-ium | CHEMBL55140 | [(3-Methyl-pyridin-2-ylamino)-phosphono-methyl]-phosphonic acid(NE97200) | [(3-methyl-pyridin-2-ylamino)-phosphono-methyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C7H12N2O6P2
Mol. Mass.:
282.1275
SMILES:
Cc1cccnc1NC(P(O)(O)=O)P(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: