Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50395131
Substrate
n/a
Meas. Tech.
ChEMBL_859788 (CHEMBL2169616)
EC50
6100±n/a nM
Citation
 Korboukh, I; Hull-Ryde, EA; Rittiner, JE; Randhawa, AS; Coleman, J; Fitzpatrick, BJ; Setola, V; Janzen, WP; Frye, SV; Zylka, MJ; Jin, J Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice. J Med Chem 55:6467-77 (2012) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50395131
Synonyms:
CHEMBL2163563
Type:
Small organic molecule
Emp. Form.:
C31H37ClN5O7P
Mol. Mass.:
658.082
SMILES:
O[C@@H]1[C@@H](COP(=O)(OCCc2ccccc2)OCCc2ccccc2)O[C@H]([C@@H]1O)n1cnc2c(NC3CCCC3)nc(Cl)nc12 |r|
Structure:
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