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Target
Histone-lysine N-methyltransferase SUV39H1
Ligand
BDBM50396026
Substrate
n/a
Meas. Tech.
ChEMBL_861232 (CHEMBL2173370)
IC50
530±n/a nM
Citation
 Decarlo, D; Hadden, MK Oncoepigenomics: making histone lysine methylation count. Eur J Med Chem 56:179-194 (2012) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase SUV39H1
Synonyms:
H3-K9-HMTase 1 | Histone H3-K9 methyltransferase 1 | KMT1A | Lysine N-methyltransferase 1A | Position-effect variegation 3-9 homolog | SUV39H | SUV39H1 | SUV91_HUMAN | Su(var)3-9 homolog 1 | Suppressor of variegation 3-9 homolog 1
Type:
PROTEIN
Mol. Mass.:
47917.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1473655
Residue:
412
Sequence:
MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKTPRHLDPSLANYLVQKAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWAPTGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKYLF
  
Inhibitor
Name:
BDBM50396026
Synonyms:
CHEMBL2172426
Type:
Small organic molecule
Emp. Form.:
C30H28N6O4S4
Mol. Mass.:
664.841
SMILES:
CN1C(=O)[C@@]23C[C@]4([C@H](Nc5ccccc45)N2C(=O)[C@]1(C)SS3)[C@]12C[C@]34SS[C@](C)(N(C)C3=O)C(=O)N4[C@H]1Nc1ccccc21 |r,TLB:17:16:1.2:20.21,7:15:1.2:20.21,THB:34:33:29.31:26.25,36:35:29.31:26.25|
Structure:
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