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Target
Tyrosine-protein kinase SYK
Ligand
BDBM50396076
Substrate
n/a
Meas. Tech.
ChEMBL_861810 (CHEMBL2173403)
IC50
10000±n/a nM
Citation
 Singh, R; Masuda, ES; Payan, DG Discovery and development of spleen tyrosine kinase (SYK) inhibitors. J Med Chem 55:3614-43 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_RAT | Syk
Type:
PROTEIN
Mol. Mass.:
71541.93
Organism:
Rattus norvegicus
Description:
ChEMBL_1348392
Residue:
629
Sequence:
MAGNAVDNANHLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAHHYTIERELNGTYAISGGRAHASPADLCHYHSQEPEGLVCLLKKPFNRPPGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGNISRDESEQTVLIGSKTNGKFLIRARDNNGSFALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLLRVLTVPCQKIGVQMGHPGSSNAHPVTWSPGGIISRIKSYSFPKPGHKKPPPPQGSRPESTVSFNPYEPTGGAWGPDRGLQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAAWGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYFKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPPGCPREMYDLMFLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM50396076
Synonyms:
CHEMBL2170739
Type:
Small organic molecule
Emp. Form.:
C18H20N2O
Mol. Mass.:
280.3642
SMILES:
Cc1ccc2c(c1C)n(CCCN)c1ccccc1c2=O
Structure:
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