Target
Advanced glycosylation end product-specific receptor
Ligand
BDBM50397837
Substrate
n/a
Meas. Tech.
ChEMBL_876306 (CHEMBL2185367)
IC50
4600±n/a nM
Citation
 Han, YTChoi, GISon, DKim, NJYun, HLee, SChang, DJHong, HSKim, HHa, HJKim, YHPark, HJLee, JSuh, YG Ligand-based design, synthesis, and biological evaluation of 2-aminopyrimidines, a novel series of receptor for advanced glycation end products (RAGE) inhibitors. J Med Chem 55:9120-35 (2012) [PubMed]  Article 
Target
Name:
Advanced glycosylation end product-specific receptor
Synonyms:
AGER | RAGE | RAGE_HUMAN | Receptor for advanced glycosylation end products
Type:
PROTEIN
Mol. Mass.:
42800.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1339877
Residue:
404
Sequence:
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
  
Inhibitor
Name:
BDBM50397837
Synonyms:
CHEMBL2179074
Type:
Small organic molecule
Emp. Form.:
C28H28Cl2N4O
Mol. Mass.:
507.454
SMILES:
CCN(CC)CCOc1ccccc1Nc1nc(cc(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1
Structure:
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