Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50398057
Substrate
n/a
Meas. Tech.
ChEMBL_873466 (CHEMBL2186561)
Ki
0.960000±n/a nM
Citation
 James, ML; Shen, B; Zavaleta, CL; Nielsen, CH; Mesangeau, C; Vuppala, PK; Chan, C; Avery, BA; Fishback, JA; Matsumoto, RR; Gambhir, SS; McCurdy, CR; Chin, FT New positron emission tomography (PET) radioligand for imagings-1 receptors in living subjects. J Med Chem 55:8272-82 (2012) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50398057
Synonyms:
CHEMBL2181924
Type:
Small organic molecule
Emp. Form.:
C18H25FN2OS
Mol. Mass.:
336.467
SMILES:
FCCCc1ccc2n(CCN3CCCCCC3)c(=O)sc2c1
Structure:
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