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Target
5-hydroxytryptamine receptor 4
Ligand
BDBM50398588
Substrate
n/a
Meas. Tech.
ChEMBL_873969 (CHEMBL2185658)
EC50
1.5±n/a nM
Citation
 Brodney, MA; Johnson, DE; Sawant-Basak, A; Coffman, KJ; Drummond, EM; Hudson, EL; Fisher, KE; Noguchi, H; Waizumi, N; McDowell, LL; Papanikolaou, A; Pettersen, BA; Schmidt, AW; Tseng, E; Stutzman-Engwall, K; Rubitski, DM; Vanase-Frawley, MA; Grimwood, S Identification of multiple 5-HT4 partial agonist clinical candidates for the treatment of Alzheimer's disease. J Med Chem 55:9240-54 (2012) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-HT-4 | 5-HT4 | 5-HT4L | 5-HT4S | 5-hydroxytryptamine receptor 4 | 5HT4R_RAT | Htr4 | Serotonin (5-HT) receptor | Serotonin 4 (5-HT4) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46117.31
Organism:
RAT
Description:
5-HT4 HTR4 RAT::Q62758
Residue:
406
Sequence:
MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
  
Inhibitor
Name:
BDBM50398588
Synonyms:
CHEMBL2179582
Type:
Small organic molecule
Emp. Form.:
C23H32FN3O4
Mol. Mass.:
433.5163
SMILES:
CC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc12
Structure:
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