Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50399570
Substrate
n/a
Meas. Tech.
ChEMBL_878513 (CHEMBL2188178)
Ki
1.07±n/a nM
Citation
 Federico, S; Ciancetta, A; Sabbadin, D; Paoletta, S; Pastorin, G; Cacciari, B; Klotz, KN; Moro, S; Spalluto, G Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists. J Med Chem 55:9654-68 (2012) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50399570
Synonyms:
CHEMBL2180933
Type:
Small organic molecule
Emp. Form.:
C19H17N7O
Mol. Mass.:
359.3846
SMILES:
Cc1ccc(CNc2nc3nn(C)cc3c3nc(nn23)-c2ccco2)cc1
Structure:
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