Target
Histone deacetylase 8
Ligand
BDBM50399674
Substrate
n/a
Meas. Tech.
ChEMBL_878900 (CHEMBL2185051)
IC50
180±n/a nM
Citation
 Suzuki, TOta, YRi, MBando, MGotoh, AItoh, YTsumoto, HTatum, PRMizukami, TNakagawa, HIida, SUeda, RShirahige, KMiyata, N Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries. J Med Chem 55:9562-75 (2012) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50399674
Synonyms:
CHEMBL2178344
Type:
Small organic molecule
Emp. Form.:
C17H16N4O2
Mol. Mass.:
308.3345
SMILES:
ONC(=O)c1cccc(c1)-c1cn(CCc2ccccc2)nn1
Structure:
Search PDB for entries with ligand similarity: