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Target
D(3) dopamine receptor
Ligand
BDBM50400516
Substrate
n/a
Meas. Tech.
ChEMBL_879545 (CHEMBL2208954)
Ki
1.6±n/a nM
Citation
 Chen, J; Collins, GT; Levant, B; Woods, J; Deschamps, JR; Wang, S CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full Agonist. ACS Med Chem Lett 2:620-625 (2011) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50400516
Synonyms:
CHEMBL2203407
Type:
Small organic molecule
Emp. Form.:
C29H38N4O2S
Mol. Mass.:
506.703
SMILES:
CCCN(CC[C@@]1(O)CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1 |r,wU:10.13,6.6,wD:26.28,6.5,(39.39,-23.82,;39.39,-22.28,;38.06,-21.51,;38.06,-19.97,;39.39,-19.2,;40.73,-19.97,;42.06,-19.2,;42.05,-20.74,;43.39,-19.98,;44.72,-19.22,;44.73,-17.68,;43.4,-16.91,;42.06,-17.67,;46.07,-16.92,;47.4,-17.7,;47.39,-19.24,;48.77,-16.96,;48.76,-15.42,;50.08,-14.66,;51.4,-15.42,;52.73,-14.65,;54.07,-15.42,;54.06,-16.96,;52.73,-17.73,;51.4,-16.95,;50.09,-17.71,;36.73,-19.2,;36.73,-17.66,;35.4,-16.88,;34.07,-17.65,;32.59,-17.17,;31.68,-18.42,;30.14,-18.42,;32.59,-19.67,;34.07,-19.2,;35.4,-19.96,)|
Structure:
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