Target
Histone-lysine N-methyltransferase SUV39H2
Ligand
BDBM50400781
Substrate
n/a
Meas. Tech.
ChEMBL_879132 (CHEMBL2209077)
IC50
>100000±n/a nM
Citation
 Verma, SKTian, XLaFrance, LVDuquenne, CSuarez, DPNewlander, KARomeril, SPBurgess, JLGrant, SWBrackley, JAGraves, APScherzer, DAShu, AThompson, COtt, HMAller, GSMachutta, CADiaz, EJiang, YJohnson, NWKnight, SDKruger, RGMcCabe, MTDhanak, DTummino, PJCreasy, CLMiller, WH Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett 3:1091-1096 (2012) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase SUV39H2
Synonyms:
H3-K9-HMTase 2 | Histone H3-K9 methyltransferase 2 | Histone-lysine N-methyltransferase SUV39H2 | Histone-lysine N-methyltransferase SUV39H2 (Suv39H2) | KMT1B | Lysine N-methyltransferase 1B | SUV39H2 | SUV92_HUMAN | Su(var)3-9 homolog 2 | Suppressor of variegation 3-9 homolog 2
Type:
Enzyme
Mol. Mass.:
46692.47
Organism:
Homo sapiens (Human)
Description:
Q9H5I1
Residue:
410
Sequence:
MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKDMEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
  
Inhibitor
Name:
BDBM50400781
Synonyms:
CHEMBL2204997
Type:
Small organic molecule
Emp. Form.:
C31H39N7O2
Mol. Mass.:
541.6871
SMILES:
CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(C)CC1
Structure:
Search PDB for entries with ligand similarity: