Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50281629
Substrate
n/a
Meas. Tech.
ChEMBL_879302 (CHEMBL2208700)
IC50
275±n/a nM
Citation
 Meanwell, NA Synopsis of some recent tactical application of bioisosteres in drug design. J Med Chem 54:2529-91 (2011) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50281629
Synonyms:
4'-[(2-Trifluoromethyl-5,6,7,8-tetrahydro-quinazolin-4-ylamino)-methyl]-biphenyl-2-carboxylic acid | CHEMBL166143
Type:
Small organic molecule
Emp. Form.:
C23H20F3N3O2
Mol. Mass.:
427.419
SMILES:
OC(=O)c1ccccc1-c1ccc(CNc2nc(nc3CCCCc23)C(F)(F)F)cc1
Structure:
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