Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50336708
Substrate
n/a
Meas. Tech.
ChEMBL_879270 (CHEMBL2208623)
IC50
390±n/a nM
Citation
 Meanwell, NA Synopsis of some recent tactical application of bioisosteres in drug design. J Med Chem 54:2529-91 (2011) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50336708
Synonyms:
(1-(3,5-Difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl)(phenyl)methanone | CHEMBL1673027
Type:
Small organic molecule
Emp. Form.:
C17H11F2NO2
Mol. Mass.:
299.2715
SMILES:
Oc1c(F)cc(cc1F)-n1ccc(c1)C(=O)c1ccccc1
Structure:
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