Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50391226
Substrate
n/a
Meas. Tech.
ChEMBL_53615 (CHEMBL858229)
Ki
19498±n/a nM
Citation
 Selassie, CD; Li, RL; Poe, M; Hansch, C On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase. J Med Chem 34:46-54 (1991) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
1.5.1.3 | DHFR | DYR_CHICK
Type:
n/a
Mol. Mass.:
21652.69
Organism:
Gallus gallus (Chicken)
Description:
n/a
Residue:
189
Sequence:
VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSIPEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAVYKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFEVYQKSVLAQ
  
Inhibitor
Name:
BDBM50391226
Synonyms:
CHEMBL265493
Type:
Small organic molecule
Emp. Form.:
C11H12N4
Mol. Mass.:
200.2398
SMILES:
Nc1ncc(Cc2ccccc2)c(N)n1
Structure:
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