Reaction Details Report a problem with these data
Target
Dihydrofolate reductase type 1
Ligand
BDBM50405988
Substrate
n/a
Meas. Tech.
ChEBML_54571
Ki
9.5±n/a nM
Citation
 Selassie, CD; Li, RL; Poe, M; Hansch, C On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase. J Med Chem 34:46-54 (1991) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase type 1
Synonyms:
DYR1_ECOLX | dhfrI
Type:
PROTEIN
Mol. Mass.:
17574.87
Organism:
Escherichia coli
Description:
ChEMBL_54248
Residue:
157
Sequence:
MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG
  
Inhibitor
Name:
BDBM50405988
Synonyms:
CHEMBL57343
Type:
Small organic molecule
Emp. Form.:
C16H21N5O2
Mol. Mass.:
315.3702
SMILES:
CCc1cc(Cc2cnc(N)nc2N)cc(NC(C)=O)c1CO
Structure:
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