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Target
Dihydrofolate reductase type 1
Ligand
BDBM50138687
Substrate
n/a
Meas. Tech.
ChEBML_54571
Ki
129±n/a nM
Citation
 Selassie, CD; Li, RL; Poe, M; Hansch, C On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase. J Med Chem 34:46-54 (1991) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase type 1
Synonyms:
DYR1_ECOLX | dhfrI
Type:
PROTEIN
Mol. Mass.:
17574.87
Organism:
Escherichia coli
Description:
ChEMBL_54248
Residue:
157
Sequence:
MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG
  
Inhibitor
Name:
BDBM50138687
Synonyms:
5-(4-(benzyloxy)benzyl)pyrimidine-2,4-diamine | 5-(4-Benzyloxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL56146
Type:
Small organic molecule
Emp. Form.:
C18H18N4O
Mol. Mass.:
306.3617
SMILES:
Nc1ncc(Cc2ccc(OCc3ccccc3)cc2)c(N)n1
Structure:
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