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Reaction Details
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TargetHistamine H2 receptor
LigandBDBM50406534
Substrate/Competitorn/a
Meas. Tech.ChEMBL_85335
Kd 1202.26±n/a nM
Citation Donetti, ABastiaans, HMKramer, KBietti, GCereda, EDubini, EMondoni, MBast, ATimmerman, H Substituent effect on the stereochemistry of H2-receptor antagonists of the phenylformamidine series. A conformation-dependent mode of interaction with the H2 receptor. J Med Chem34:1772-6 (1991) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H2 receptor
Name:Histamine H2 receptor
Synonyms:Gastric receptor I | H2R | HISTAMINE H2 | Histamine H2-Gs alpha S
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40567.22
Organism:Cavia porcellus (domestic guinea pig)
Description:For the H2 receptor-binding assays, guinea pig striatum was used.
Residue:359
Sequence:
MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSL
AVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYH
QLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
Blast this sequence in BindingDB or PDB
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BDBM50406534
NameBDBM50406534
Synonyms:CHEMBL50960
TypeSmall organic molecule
Emp. Form.C11H12N4
Mol. Mass.200.2398
SMILESCNC=Nc1ccc(cc1)-c1c[nH]cn1 |w:2.1|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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