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Target
Cathepsin K
Ligand
BDBM50374296
Substrate
n/a
Meas. Tech.
ChEMBL_365368 (CHEMBL871198)
Ki
3.3±n/a nM
Citation
 Palmer, JT; Hirschbein, BL; Cheung, H; McCarter, J; Janc, JW; Yu, ZW; Wesolowski, G Keto-1,3,4-oxadiazoles as cathepsin K inhibitors. Bioorg Med Chem Lett 16:2909-14 (2006) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50374296
Synonyms:
CHEMBL379622
Type:
Small organic molecule
Emp. Form.:
C23H27F3N4O6
Mol. Mass.:
512.4789
SMILES:
CCC[C@H](NC(=O)C1(CCCCC1)NC(=O)c1ccc(OC(F)(F)F)cc1)C(=O)c1nnc(OC)o1
Structure:
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