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Target
Tryptase
Ligand
BDBM50411006
Substrate
n/a
Meas. Tech.
ChEMBL_371008 (CHEMBL868506)
Ki
365±n/a nM
Citation
 Palmer, JT; Rydzewski, RM; Mendonca, RV; Sperandio, D; Spencer, JR; Hirschbein, BL; Lohman, J; Beltman, J; Nguyen, M; Liu, L Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors. Bioorg Med Chem Lett 16:3434-9 (2006) [PubMed]  Article 
Target
Name:
Tryptase
Synonyms:
Mcpt7 | TRYB1_MOUSE | Tpsab1 | Tryptase alpha/beta-1
Type:
PROTEIN
Mol. Mass.:
30334.87
Organism:
Mus musculus
Description:
ChEMBL_385583
Residue:
273
Sequence:
MLKLLLLTLPLLSSLVHAAPGPAMTREGIVGGQEAHGNKWPWQVSLRANDTYWMHFCGGSLIHPQWVLTAAHCVGPDVADPNKVRVQLRKQYLYYHDHLMTVSQIITHPDFYIVQDGADIALLKLTNPVNISDYVHPVPLPPASETFPSGTLCWVTGWGNIDNGVNLPPPFPLKEVQVPIIENHLCDLKYHKGLITGDNVHIVRDDMLCAGNEGHDSCQGDSGGPLVCKVEDTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKDF
  
Inhibitor
Name:
BDBM50411006
Synonyms:
CHEMBL539088
Type:
Small organic molecule
Emp. Form.:
C30H29Cl2FN4O4
Mol. Mass.:
599.48
SMILES:
NCCCC[C@H](NC(=O)c1ccc(F)cc1)C(=O)c1noc(Cc2ccc(OCCc3ccc(Cl)c(Cl)c3)cc2)n1 |r|
Structure:
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