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Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50411338
Substrate
n/a
Meas. Tech.
ChEMBL_439007 (CHEMBL889353)
Ki
4.7±n/a nM
Citation
 McDonald, IM; Black, JW; Buck, IM; Dunstone, DJ; Griffin, EP; Harper, EA; Hull, RA; Kalindjian, SB; Lilley, EJ; Linney, ID; Pether, MJ; Roberts, SP; Shaxted, ME; Spencer, J; Steel, KI; Sykes, DA; Walker, MK; Watt, GF; Wright, L; Wright, PT; Xun, W Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion. J Med Chem 50:3101-12 (2007) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCKBR | Cholecystokinin B | Cholecystokinin B receptor | GASR_CANLF | Gastrin/cholecystokinin type B receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48544.19
Organism:
Dog
Description:
Cholecystokinin B 0 Dog::P30552
Residue:
453
Sequence:
MELLKLNRSAQGSGAGPGASLCRAGGALLNSSGAGNLSCEPPRLRGAGTRELELAIRVTLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVVCKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIIATWMLSGLLMVPYPVYTAVQPAGGARALQCVHRWPSARVRQTWSVLLLLLLFFVPGVVMAVAYGLISRELYLGLRFDEDSDSESRVRSQGGLRGGAGPGPAPPNGSCRPEGGLAGEDGDGCYVQLPRSRQTLELSALTAPTPGPGGGPRPYQAKLLAKKRVVRMLLVIVVLFFLCWLPLYSANTWRAFDSSGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50411338
Synonyms:
CHEMBL227254
Type:
Small organic molecule
Emp. Form.:
C30H37N9O3
Mol. Mass.:
571.6733
SMILES:
CN(c1nnn[nH]1)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 |t:18|
Structure:
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