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Target
Substance-P receptor
Ligand
BDBM50415264
Substrate
n/a
Meas. Tech.
ChEMBL_604256 (CHEMBL1050401)
Ki
20.0±n/a nM
Citation
 Sabbatini, FM; Di Fabio, R; Griffante, C; Pentassuglia, G; Zonzini, L; Melotto, S; Alvaro, G; Capelli, AM; Pippo, L; Perdona', E; St Denis, Y; Costa, S; Corsi, M Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK(1) receptor antagonists. Bioorg Med Chem Lett 20:623-7 (2010) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50415264
Synonyms:
CHEMBL591074
Type:
Small organic molecule
Emp. Form.:
C25H24F7N3O
Mol. Mass.:
515.4664
SMILES:
Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(cc(c1)C(F)(F)F)C(F)(F)F |r,c:21|
Structure:
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