Reaction Details Report a problem with these data
Target
Cytochrome P450 3A6
Ligand
BDBM50014323
Substrate
n/a
Meas. Tech.
ChEMBL_738411 (CHEMBL1743488)
Ki
80100±n/a nM
Citation
 Fontana, E; Dansette, PM; Poli, SM Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab 6:413-54 (2005) [PubMed]  Article 
Target
Name:
Cytochrome P450 3A6
Synonyms:
CP3A6_RABIT | CYP3A6 | CYPIIIA6 | Cytochrome P450-3C
Type:
PROTEIN
Mol. Mass.:
57463.93
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_738411
Residue:
501
Sequence:
MDLIFSLETWVLLAASLVLLYLYGTSTHGLFKKMGIPGPTPLPFIGTILEYRKGIWDFDIECRKKYGKMWGLFDGRQPLMVITDPDMIKTVLVKECYSVFTNRRSFGPVGFMKKAVSISEDEDWKRVRTLLSPTFTSGKLKEMLPIIAQYGDVLVKNLRQEAEKGKPVDLKEIFGAYSMDVITGTSFGVNIDSLRNPQDPFVKNVRRLLKFSFFDPLLLSITLFPFLTPIFEALHISMFPKDVMDFLKTSVEKIKDDRLKDKQKRRVDFLQLMINSQNSKEIDSHKALDDIEVVAQSIIILFAGYETTSSTLSFIMHLLATHPDVQQKLQEEIDTLLPNKELATYDTLVKMEYLDMVVNETLRLYPIAGRLERVCKKDVDINGTFIPKGTIVMMPTYALHRDPQHWTEPDEFRPERFSKKNKDNINPYIYHPFGAGPRNCLGMRFALMNIKLALVRLMQNFSFKLCKETQVPLKLGKQGLLQPEKPIVLKVVSRDGIIRGA
  
Inhibitor
Name:
BDBM50014323
Synonyms:
2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE | 2-Phenyl-benzo[h]chromen-4-one | 7,8-Benzoflavone | CHEMBL283196 | alpha-naphthoflavone
Type:
Small organic molecule
Emp. Form.:
C19H12O2
Mol. Mass.:
272.2974
SMILES:
O=c1cc(oc2c3ccccc3ccc12)-c1ccccc1
Structure:
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