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Target
Mitogen-activated protein kinase 8
Ligand
BDBM15913
Substrate
n/a
Meas. Tech.
ChEMBL_840522 (CHEMBL2089873)
IC50
4.7±n/a nM
Citation
 Kusakabe, K; Ide, N; Daigo, Y; Itoh, T; Higashino, K; Okano, Y; Tadano, G; Tachibana, Y; Sato, Y; Inoue, M; Wada, T; Iguchi, M; Kanazawa, T; Ishioka, Y; Dohi, K; Tagashira, S; Kido, Y; Sakamoto, S; Yasuo, K; Maeda, M; Yamamoto, T; Higaki, M; Endoh, T; Ueda, K; Shiota, T; Murai, H; Nakamura, Y Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. ACS Med Chem Lett 3:560-564 (2012) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 8
Synonyms:
JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48297.57
Organism:
Homo sapiens (Human)
Description:
JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
427
Sequence:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAAGPLGCCR
  
Inhibitor
Name:
BDBM15913
Synonyms:
2-pyridinecarboxamide deriv. 8c | 4-Amino-5-cyano-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide | 4-amino-5-cyano-6-ethoxy-N-[(4-methanesulfonylphenyl)methyl]pyridine-2-carboxamide | CHEMBL424872
Type:
Small organic molecule
Emp. Form.:
C17H18N4O4S
Mol. Mass.:
374.414
SMILES:
CCOc1nc(cc(N)c1C#N)C(=O)NCc1ccc(cc1)S(C)(=O)=O
Structure:
Search PDB for entries with ligand similarity: