Target
Protein-glutamine gamma-glutamyltransferase K
Ligand
BDBM50420468
Substrate
n/a
Meas. Tech.
ChEMBL_841032 (CHEMBL2091158)
IC50
2600±n/a nM
Citation
 Prime, MEAndersen, OABarker, JJBrooks, MACheng, RKToogood-Johnson, ICourtney, SMBrookfield, FAYarnold, CJMarston, RWJohnson, PDJohnsen, SFPalfrey, JJVaidya, DErfan, SIchihara, OFelicetti, BPalan, SPedret-Dunn, ASchaertl, SSternberger, IEbneth, AScheel, AWinkler, DToledo-Sherman, LBeconi, MMacdonald, DMuñoz-Sanjuan, IDominguez, CWityak, J Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J Med Chem 55:1021-46 (2012) [PubMed]  Article 
Target
Name:
Protein-glutamine gamma-glutamyltransferase K
Synonyms:
KTG | Protein-glutamine gamma-glutamyltransferase K | TGM1 | TGM1_HUMAN | Transglutaminase-1 (TG1)
Type:
Protein
Mol. Mass.:
89778.63
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
817
Sequence:
MMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADDDWGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLSSRSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGTHVIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDACLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESIKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMREDITYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVMLINHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLVDQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVTLTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA
  
Inhibitor
Name:
BDBM50420468
Synonyms:
CHEMBL2086524
Type:
Small organic molecule
Emp. Form.:
C23H32N4O4S
Mol. Mass.:
460.59
SMILES:
C=CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C(=O)N1CCCC2CCCCC12
Structure:
Search PDB for entries with ligand similarity: