Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM50421229
Substrate
n/a
Meas. Tech.
ChEMBL_839905 (CHEMBL2090106)
IC50
>200000±n/a nM
Citation
 Chen, P; Horton, LB; Mikulski, RL; Deng, L; Sundriyal, S; Palzkill, T; Song, Y 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-ß-lactamases. Bioorg Med Chem Lett 22:6229-32 (2012) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase | metallo-beta-lactamase IMP-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27125.88
Organism:
Pseudomonas aeruginosa
Description:
gi_27368096
Residue:
246
Sequence:
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPSKPSN
  
Inhibitor
Name:
BDBM50421229
Synonyms:
CHEMBL2087631
Type:
Small organic molecule
Emp. Form.:
C10H8ClNO2S
Mol. Mass.:
241.694
SMILES:
OC(=O)[C@@H]1CSC(=N1)c1ccc(Cl)cc1 |r,c:6|
Structure:
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