Reaction Details Report a problem with these data
Target
Alpha-1A adrenergic receptor
Ligand
BDBM50001922
Substrate
n/a
Meas. Tech.
ChEMBL_33758 (CHEMBL650231)
EC50
63±n/a nM
Citation
 Navas, F; Bishop, MJ; Garrison, DT; Hodson, SJ; Speake, JD; Bigham, EC; Drewry, DH; Saussy, DL; Liacos, JH; Irving, PE; Gobel, MJ 2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series. Bioorg Med Chem Lett 12:575-9 (2002) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
  
Inhibitor
Name:
BDBM50001922
Synonyms:
2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; hydrochloride | Albalon | CHEMBL1706 | NAPHAZOLINE HYDROCHLORIDE | Nafazair | Naphazoline | Naphazoline Nitrate | Naphcon forte | Opcon | Vasocon | cid_11079
Type:
Small organic molecule
Emp. Form.:
C14H14N2
Mol. Mass.:
210.2744
SMILES:
C(C1=NCCN1)c1cccc2ccccc12 |t:1|
Structure:
Search PDB for entries with ligand similarity: