Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50421914
Substrate
n/a
Meas. Tech.
ChEBML_201733
IC50
2.5±n/a nM
Citation
 Russell, MG; Baker, R; Billington, DC; Knight, AK; Middlemiss, DN; Noble, AJ Benz[f]isoquinoline analogues as high-affinity sigma ligands. J Med Chem 35:2025-33 (1992) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50421914
Synonyms:
CHEMBL543810
Type:
Small organic molecule
Emp. Form.:
C17H23N
Mol. Mass.:
241.3712
SMILES:
C(C1CC1)N1CC[C@@H]2[C@@H](CCc3ccccc23)C1 |r|
Structure:
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